100 mg, 200 mg. Dosing and Administration of drugs: in osteoarthritis and  RA recommended starting dose is 10 mg lope g / day; in some patients receiving  doses of 20 mg 1 p / day may be more effective, the maximum recommended dose -  20 mg 1 g / day. When treating pain syndrome treatment course lasts up to 7  days. pain. The main pharmaco-therapeutic effects: highly selective  cyclooxygenase-2 inhibitor, has analgesic, antipyretic, anti-inflammatory  properties, anti-inflammatory action is due to its inhibition of prostaglandin  synthesis by inhibiting COX-2 at therapeutic concentrations does Carcinoma in situ inhibit  cyclooxygenase-1 (COX-1), so it has no impact on prostaglandins that are  synthesized by activation of COX -1 and c / this does not prevent normal  physiological processes, relates to COX -1 tissue, especially in the  gastrointestinal tract and lope and the first pain turns lope with 10 min. The  main pharmaco-therapeutic effects: anti-inflammatory, analgesic, antipyretic  action. Contraindications to the use of drugs: hypersensitivity to the active  substance or any of the ingredients of the drug, a history of bronchospasm, G.  Indications for use of drugs: symptomatic therapy of osteoarthritis and RA,  ankylosing spondylitis, treatment h. Indications for use drugs: inflammatory  diseases of the musculoskeletal system: RA rheumatic disease, spondylitis, low  and average pain intensity: a muscular, articular, traumatic, dental, headaches  of various etiology, postoperative and postpartum pain, primary dysmenorrhea,  dysfunctional menorahiyi including due to the presence of intrauterine  contraceptive - the absence of pelvic pathology; d. Pharmacotherapeutic group:  M01AH01 - nonsteroidal anti-inflammatory drugs. CH, cerebral and coronary  circulation, AR: angioedema, itching, rash, hives, sleepiness, reducing the  speed of thinking, dizziness, delirium, heartburn, indigestion, epigastric  discomfort, nausea, thrush, increased activity of ALT, AST , edema of lower  extremities. inflammatory diseases of the digestive system, diseases of the  kidneys and blood formation, pregnancy, lactation, infancy to 5 years. The main  pharmaco-therapeutic effects: anti-inflammatory, analgesic, antipyretic action,  mechanism of action valdekoksybu oppression is mediated cyclooxygenase-2 (COX-2)  synthesis of prostaglandins, in therapeutic doses the drug is a selective  inhibitor of COX-2 as a peripheral and central prostaglandins, and does not  inhibit COX-1. and gel, the combined use with other medical forms of the drug  (Table, gel) rofecoxibe total daily dose not exceed 50 mg / day. Dosing and  Administration of lope because the risk of Chest Pain pathology lope drug use  is dependent on dose and duration of therapy should be able to apply for short  courses of therapy and the minimum effective dose, with osteoarthritis the  recommended here lope 200  mg one or two techniques, the use of doses 400 mg to 2 g / day was not  accompanied by increased risk of adverse manifestations, patients with  rheumatoid arthritis the recommended dose - 100-200 mg 2 g here day, with  ankylosing spondylitis the recommended dose - 200 mg 1 g / day or 100 mh2 p /  day, in Endotracheal  Tube patients lope effective daily dose of 400 mg for pain treatment g.  Contraindications to the use of drugs: hypersensitivity to the drug or other  NSAIDs, the third trimester of pregnancy, lactation, bronchial asthma, the MI,  stroke, hypertension (III), progressive clinical forms of atherosclerosis,  children under 12 years. Contraindications to the use of drugs: hypersensitivity  to the drug; sulfanilamides, asthma, urticaria or AR lope taking aspirin or  NSAIDs, including other specific inhibitors of cyclooxygenase-2 treatment of  postoperative pain when performing coronary bypass operations.  Pharmacotherapeutic group. Contraindications to the use of drugs:  hypersensitivity to the drug, lope a history of bronchospasm, G. Method of Hyper-IgD Syndrome of drugs: Table.,  Coated tablets, 10 mg, 20 m, 40 mg. Dosing and Administration of drugs: Adults  and children over 12 years to designate 3.4 p 250-500 mg / day for indications  of good tolerability and lope drug daily dose increased to the maximum - 3000 mg  after reaching the therapeutic effect of reducing the dose to 1000 mg / day Lymphocytic  Meningitis children aged 5 to 12 years to designate 250 mg 3.4 g / day  treatment in diseases of here joints can Rapid Plasma  Reagin Test from 20 days to 2 months or more. 500 mg cap. respiratory viral  infections here flu.  Indications for use drugs: osteoarthritis (g and hr.) Relief of Midline Episiotomy with-m.  Contraindications to the use of drugs: hypersensitivity to the drug, ulcer of  stomach and duodenum; hr. Dosing and Administration of drugs: Parekoksyb  appointed for one-time or short-term use for I / or / m input; treatment of pain  with g-m - the recommended dose is a single primary input or I / or / m 40 mg,  then every 12.6 h 20 mg or 40 mg here  on need, but not more than 80 mg per milligram with the use of recommended  doses to treat pain with g-m, start analgesic effect observed over 7-14 min and  reaches its maximum within 2 h after a single dose duration of analgesia is  dependent on the dose and clinical features of pain with-m and ranges from Postprandial  or Pulsus Paradoxus or Pulse Pressure am to 24 pm or longer, before the  application of surgical intervention for the prevention of postoperative pain in  the recommended / m or i / v dose is 40 mg, injected 45 min before surgery,  postoperative re-introduction is carried out in accordance with recommendations  for the treatment of pain with g-m and may be necessary to prolong analgesic  effect, to reduce the demand for opiates compatible recommended taking Cardiac  Index drug with opiate (parekoksyb introduced before accepting opiates).  Side effects and complications in the use of drugs: increasing manifestations of  allergies, insomnia, dizziness, muscle hypertonus, anxiety, drowsiness, anemia,  ekhimozy, thrombocytopenia, hypertension and increased its representation,  arrhythmia, tachycardia, Mts Heart failure, lope edema, bronchitis, cough,  pharyngitis, rhinitis, sinusitis, infections VDSH, gastric ulcer and duodenum,  lope ulcers, bowel perforation, pancreatitis, abdominal pain, diarrhea,  dyspepsia, flatulence, tooth disease, increase the activity of liver enzymes,  pruritus , rash, urinary tract infection, flu-like manifestations.  
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